A new study from Duke University Medical Center and Columbia University claims that Gastric Bypass sometimes improves type 2 diabetes long before the patients lose weight.
Even thought the study was small; 21 in all. The surgery patients had lower levels of amino acids that have been linked to insulin resistance in their systems compared to the dieters. The 10 gastric bypass patients and the 11 calorie restricted dieters all lost just a fraction of the overall weight when the analysis was conducted. But researcher says the preliminary findings are tremendous and hopefully could one day lead to diabetes treatments.
Study researcher Blandine Laferrere, MD, of Columbia University’s St. Luke’s and Roosevelt Hospital Center, tells WebMD, “Certainly weight loss by any means improves type 2 diabetes, but there is something else going on with gastric bypass surgery,”
“Surgery puts the diabetes into remission. Most of the research has focused on changes in gut hormones, but we have shown that a decline in specific circulating amino acids also occurs.”
The study only included obese people with a BMI of 35 and greater from the gastric bypass side, while the dieters were strictly monitored on a 1000 calorie restricted diet.
At the time of the study all participants had lost an average of 20lbs. The surgery patients took only one month to achieve the 20lb goal while most of the dieters took two months to reach the 20lb goal for the study.
The analysis revealed that the surgery patients had much lower levels of several types of circulating branched-chain amino acids (BCAA) and the aromatic amino acids phenylalanine (Phe) and tyrosine (Tyr).
The greatest achievement for the study was the control in blood sugar for the gastric bypass patients, all were off all diabetes drugs after that one month period. The dieters did not have the same results as almost half still needed treatment after losing the same amount of weight.
They also had greater improvements in blood sugar control. One month after surgery, all of the gastric bypass patients were off all diabetes drugs. About half the dieters still needed treatment after losing the same amount of weight.
Laferrere says this understanding could lead to new diabetes treatments that are as effective as gastric bypass surgery. “It would not be possible to offer this surgery to everyone with type 2 diabetes,” she says. “About 28 million American adults have type 2 diabetes, and about 200,000 of these surgeries are done each year.”
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